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Beilstein J. Org. Chem. 2025, 21, 1964–1972, doi:10.3762/bjoc.21.152
Graphical Abstract
Scheme 1: Representative prostaglandins and general synthetic strategy toward PGDM methyl ester 4.
Scheme 2: Retrosynthetic analysis for the first generation synthesis of PGDM methyl ester 4.
Scheme 3: Synthesis of bicyclic ketal 25.
Scheme 4: Retrosynthetic analysis for the second-generation synthesis of tricyclic PGDM methyl ester 4.
Scheme 5: Asymmetric total synthesis of tricyclic-PGDM methyl ester 4.