1 article(s) from Koskinen, Ari M. P.
Natural products and other bioactive piperidine derivatives of type B.
Jump to Figure 1
Retrosynthetic analysis of piperidines B (X = OH or leaving group, PG = protecting group).
Jump to Figure 2
Synthesis of the protected amino acids 2. (a) KOH for 1b. b) PG–X = Cbz–Cl (1a–c), Boc2O (1d).
Jump to Scheme 1
Synthesis of hydroxy ketones 7 (R = Me (a), Bn (b), Ph (c) and EtSMe (d); PG = Cbz (a–c), Boc (d)).
Jump to Scheme 2
Synthesis of amides 5e and 5f and ketone 7e.
Jump to Scheme 3
Synthesis of amino alcohols syn-9a–d and oxazolidinone 10a. (for 7a–c conditions A: H2 (1 atm), Pd/...
Jump to Scheme 4
Competition between the Michaelis–Arbuzow process and the desired cyclodehydration of amino alcohol...
Jump to Scheme 5
Initial synthesis of the trans-piperidinol 11a in diminished enantiopurity. aThe amino alcohol 9a o...
Jump to Scheme 6
Synthesis of trans-piperidinol 11a in excellent ee.
Jump to Scheme 7
Synthesis of L-733,060·HCl.
Jump to Scheme 8
Beilstein J. Org. Chem. 2014, 10, 369–383, doi:10.3762/bjoc.10.35
Subscribe to our Latest Articles RSS Feed.
Register and get informed about new articles.
Follow the Beilstein-Institut