3 article(s) from Kubyshkin, Vladimir
A) Three types of the backbone amino acid structures that are included in protein translation: glyc...
Jump to Figure 1
The set of amino acids examined in this study.
Jump to Figure 2
Design of the model system.
Jump to Figure 3
Propagation of the C4-conformation into the values of the J coupling in the C2H–C3H2 fragments.
Jump to Figure 4
Preferred side-chain conformations according to the multiplicity data.
Jump to Figure 5
A) The basicity reduction from the introduction of the dipoles reflects the preferred conformation ...
Jump to Figure 6
The lipophilicity data of the model compounds.
Jump to Figure 7
The expectations regarding the amide-bond rotation preferences in 1–4.
Jump to Figure 8
The explanation for the difference in the rotation barriers in the diastereomeric (A), 4-(trifluoro...
Jump to Figure 9
A) The structures of difluorinated model compounds 5 and 6, and the fluorine-free reference 7. B) B...
Jump to Figure 10
Beilstein J. Org. Chem. 2020, 16, 1837–1852, doi:10.3762/bjoc.16.151
A. Dependence of the lipophilicity (logP) on the number of fluorine atoms in a partially fluorinate...
Synthesis of the model compounds.
Jump to Scheme 1
Kinetics of the C-terminal ester hydrolysis.
Partitioning of the esters 1–5 between octan-1-ol and water. Insert: comparison with the other part...
Amide isomerism in the N-acetylprolyl fragment.
Jump to Scheme 2
Enhancement of the trans/cis thermodynamic preferences in the ester models as a function of the sol...
A. Four-state conformational equilibrium model used by Siebler et al.  for explanations of the elev...
Jump to Scheme 3
Elevation of the trans/cis ratio in derivatives of N-acyl proline may result from the enhanced n→π*...
Jump to Scheme 4
Synthesis of the model peptides.
Jump to Scheme 5
Mean residue molar circular dichroism (Δε) of peptides 8–10 in methanol (left) and aqueous phosphat...
Conformational analysis of the peptides by 1H DOSY NMR (D2O, 298 K). The theoretical values were ca...
Hydrolysis of the C-terminal 2,2-difluoroethyl esters of the oligopeptides in buffered deuterium ox...
Beilstein J. Org. Chem. 2017, 13, 2442–2457, doi:10.3762/bjoc.13.241
s-cis–s-trans Amide bond isomerism in an N-acyl-proline fragment.
Amino acids that have been compared in this study.
X-ray crystal structures of compounds 5–9. Carbon- grey, nitrogen – blue, oxygen – red, fluorine – ...
The relationship between the pKa of the ammonium function in the amino acid and the amide rotationa...
The double bond between C3 and C4 atoms in 3,4-dehydroproline residues induces an increase in the a...
Beilstein J. Org. Chem. 2016, 12, 589–593, doi:10.3762/bjoc.12.57
Subscribe to our Latest Articles RSS Feed.
Register and get informed about new articles.
Follow the Beilstein-Institut