4 article(s) from Leadlay, Peter F
- Full Research Paper
- Published 13 Nov 2017
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Scheme 1: The structures of clethramycin, mediomycins and related linear polyenes.
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Scheme 2: The biosynthetic gene clusters for mediomycin (med) from Streptomyces mediocidicus and clethramycin...
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Figure 1: HPLC–UV–MS analysis of polyenes. A) LC–UV (360 nm) trace of mycelium methanol extract from DSM4137 ...
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Figure 2: HPLC–UV–MS analysis of polyenes from DSM4137 wild type and mutants. A) LC–UV (360 nm) trace of myce...
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Scheme 3: The parallel pathways for the biosynthesis of mediomycin A.
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Figure 3: HPLC–UV–MS analysis of in vitro assays with amidinohydrolase Medi4948 and sulfotransferase Slf from ...
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- Full Research Paper
- Published 11 Oct 2016
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Figure 1: The structures of marginolactones azalomycin and kanchanamycin, and of the β-lactones ebelactone A ...
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Scheme 1: Comparison of the bioinformatic prediction for ebelactone biosynthesis with the known structure of ...
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Scheme 2: Proposed model for iteration of module 1 of AzlA1 in azalomycin biosynthesis. The 4-guanidinobutyry...
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Figure 2: LC–MS analysis of azalomycin F4a production. a) DSM4137 wild type; b) Δazl (azl disrupted mutant); ...
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- Full Research Paper
- Published 11 Mar 2014
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Figure 1: a) Structure of borrelidin (1); b) PKS intermediates are attached to an acyl carrier protein domain...
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Scheme 1: Retrosynthetic analysis of surrogate substrates for BorDH3 and reference molecules for enzyme assay...
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Scheme 2: Synthesis of the common precursor aldehyde 11. Compound 13 was prepared in six steps and with an ov...
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Scheme 3: Synthesis of the BorDH3 substrates. a) Thiophenolpropionate, Cy2BCl, Me2EtN, Et2O, −78 °C to −20 °C...
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Scheme 4: Synthesis of reference compounds for the BorDH3 assay. a) 24, CH2Cl2, 50 °C, 3 h (88% over two step...
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- Letter
- Published 10 Feb 2014
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Scheme 1: The proposed pathway for monensin biosynthesis in Streptomyces cinnamonensis. The polyketide syntha...
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Figure 1: LC–MS-analysis of purified monensin-related metabolites. Monensin B derivatives (peaks marked with ...
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Figure 2: (a) Crystal structure of sodium demethylmonensin A (4) (ellipsoid probability = 50%); (b) overlay o...
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