2 article(s) from Longstreet, Ashley R
The estimated demand of for nevirapine until 2015 .
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Commercial building blocks to nevirapine.
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a) Current commercial process to CAPIC and b) newly developed batch synthesis to CAPIC and its brom...
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Proposed synthesis to 2-bromo-4-methylnicotinonitrile using a continuous approach with the consider...
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a) Flow scheme to produce the enamine intermediate 5 from isopropylidenemalononitrile (4) (see Supporting Information File 1 for...
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Flow scheme to produce the enamine 5 starting from acetone and malononitrile (See Supporting Information File 1 for details).
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Comparing the long-term stability of the Al2O3 and 3 Å MS columns when the Al2O3 column temperature...
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Several byproducts were observed when producing 5 starting from acetone and malononitrile. 7 is for...
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Flow scheme to produce 2-bromo-4-methylnicotinonitrile (6b) in 81% yield from 4 with a 1 M concentr...
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Reactor scheme for the continuous synthesis of 2-bromo-4-methylnicotinonitrile (6b) with an average...
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Beilstein J. Org. Chem. 2013, 9, 2570–2578, doi:10.3762/bjoc.9.292
Methods for catalyst use in flow.
Prior results for batch α-aminoxylation reaction.
General reactor setup. A) A glass Omnifit column is packed with 1 g of proline. B) The column is th...
Schematic of the reactor setup. As the starting aldehyde and thiourea 3b (A) enter the proline pack...
The long-term stability of a proline packed bed in the α-aminoxylation reaction of hexanal. A solut...
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Reaction with 3-phenylpropionaldehyde through reactor setup.aIsolated yield, due to the instability...
Reaction with isovaleraldehyde through reactor setup.aIsolated yield, due to the instability of the...
Beilstein J. Org. Chem. 2011, 7, 1671–1679, doi:10.3762/bjoc.7.197
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