1 article(s) from Luesch, Hendrik
- Full Research Paper
- Published 28 Oct 2020
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Graphical Abstract
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Figure 1: The natural product piperine (1) is the inspiration for this work; the crystal structure is shown [14]....
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Scheme 1: The attempted synthesis of 6 (a diastereoisomer of 2) via a one-step 1,2-difluorination reaction [24]. ...
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Scheme 2: The attempted synthesis of 2 via a stepwise fluorination approach (ether series). THF = tetrahydrof...
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Scheme 3: Synthesis of compound 2 via a stepwise fluorination approach (ester series). DIC = diisopropylcarbo...
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Figure 2: Conformational analysis of 2 by DFT and NMR. The numbering scheme for NMR spins is given on structu...
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Figure 3: Analog 2 has greater stability to UV light than does piperine (1).
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Figure 4: Biological activity of piperine (1) and derivative 2. (a) Inihbition of AChE by 1 (IC50 >1000 μM) a...
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