5 article(s) from McQuade, D Tyler
- Full Research Paper
- Published 19 Jun 2020
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Figure 1: Comparing on-demand coffee and turbo Grignard pod-style machines.
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Figure 2: Ranking of the 20 most cited Grignard reagents (SciFinder March 26, 2019).
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Figure 3: On-demand prototype. A) Inside view of the pump with a flexible bag containing a yellow liquid layi...
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Figure 4: Temperature evolution measured with thermocouples along the column outer surface at three different...
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Figure 5: Stratified bicomponent column (Diba Omnifit EZ Solvent Plus) composed of magnesium (chips/powder, 1...
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Scheme 1: Continuous flow synthesis of TMPMgCl⋅LiCl with a stratified packed-bed column of activated magnesiu...
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Scheme 2: Continuous flow synthesis of TMPMgCl⋅LiBr with a stratified packed-bed column of activated magnesiu...
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Scheme 3: Continuous flow synthesis of t-AmylOMgCl⋅LiCl with a stratified packed-bed column of activated magn...
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Figure 6: Steady-state concentration stability during the conversion of iPrCl in THF (56 mL, 2.2 M) into iPrM...
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Scheme 4: Synthesis of iPrMgCl⋅LiCl on the ODR prototype.
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Scheme 5: Synthesis of HMDSMgCl⋅LiCl on the ODR prototype.
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- Full Research Paper
- Published 20 Nov 2013
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Figure 1: The estimated demand of for nevirapine until 2015 [6].
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Scheme 1: Commercial building blocks to nevirapine.
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Scheme 2: a) Current commercial process to CAPIC and b) newly developed batch synthesis to CAPIC and its brom...
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Scheme 3: Proposed synthesis to 2-bromo-4-methylnicotinonitrile using a continuous approach with the consider...
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Figure 2: a) Flow scheme to produce the enamine intermediate 5 from isopropylidenemalononitrile (4) (see Supporting Information File 1 for...
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Scheme 4: Flow scheme to produce the enamine 5 starting from acetone and malononitrile (See Supporting Information File 1 for details).
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Figure 3: Comparing the long-term stability of the Al2O3 and 3 Å MS columns when the Al2O3 column temperature...
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Scheme 5: Several byproducts were observed when producing 5 starting from acetone and malononitrile. 7 is for...
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Scheme 6: Flow scheme to produce 2-bromo-4-methylnicotinonitrile (6b) in 81% yield from 4 with a 1 M concentr...
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Scheme 7: Reactor scheme for the continuous synthesis of 2-bromo-4-methylnicotinonitrile (6b) with an average...
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Flow synthesis of a versatile fructosamine mimic and quenching studies of a fructose transport probe
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- Published 07 Oct 2013
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Scheme 1: Batch synthesis of NBDM. a) NaNO2, Amberlite IR-120 H+ (100 mL), 0 °C, water, 4 h. b) NH2OH·HCl, Na...
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Scheme 2: The initial polymer-supported nitrite set up. A solution of glucosamine hydrochloride was passed ov...
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Scheme 3: Continuous flow synthesis of the key intermediate 1-amino-2,5-anhydro-D-mannose (3).
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Figure 1: Normalized NBDM absorption and emission, 40 µM and 2 µM.
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Figure 2: NBDM fluorescence from 1–40 µM (PBS buffer). The data set was plotted in OriginPro 8.6 and fitted u...
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Figure 3: Comparison of quenching 2 µM NBDM, as measured by fluorescence intensity of Trypan Blue, Bromopheno...
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Figure 4: Comparison of quenching 2 µM NBDM, as measured by fluorescence intensity of methionine and histidin...
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- Full Research Paper
- Published 14 Dec 2011
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Figure 1: Methods for catalyst use in flow.
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Scheme 1: Prior results for batch α-aminoxylation reaction.
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Figure 2: General reactor setup. A) A glass Omnifit column is packed with 1 g of proline. B) The column is th...
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Figure 3: Schematic of the reactor setup. As the starting aldehyde and thiourea 3b (A) enter the proline pack...
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Figure 4: The long-term stability of a proline packed bed in the α-aminoxylation reaction of hexanal. A solut...
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Scheme 2: Reaction with 3-phenylpropionaldehyde through reactor setup.
aIsolated yield, due to the instability... -
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Scheme 3: Reaction with isovaleraldehyde through reactor setup.
aIsolated yield, due to the instability of the...
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- Full Research Paper
- Published 29 Apr 2009
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Scheme 1: Preparation of azide-modified AO resin 2.
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Scheme 2: Preparation of AO-TEMPO 6.
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Figure 1: The simplified microreactor setup. Empty tubing (A) is packed with functionalized AO resin and atta...
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Figure 2: The organic (colored solution) and aqueous phases (colorless solution) forming plugs at the Y-junct...
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Scheme 3: The AO-TEMPO-catalyzed oxidation of benzyl alcohol.
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Figure 3: The long-term activity of AO-TEMPO packed beds in the oxidation of 4-chlorobenzyl alcohol. A soluti...
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