2 article(s) from Natori, Yoshihiro
Graphical summary of chemically contiguous opioid vaccine approach. A) Illustration of chemically c...
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The chemically contiguous heroin–fentanyl haptens designed in this study. Grouping was based on the...
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Heroin intermediates used to synthesize HF-1 through HF-9.
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General outline of HF-1, HF-2, HF-3, HF-7 synthesis from fentanyl intermediate 5 and heroin interme...
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Synthesis of fentanyl intermediate 5. Reaction conditions: a) phthalic anhydride, AcOH, reflux, 81%...
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General outline of HF-5, HF-8, HF-9 synthesis from fentanyl intermediates 28 and 46, and heroin int...
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Parallel synthesis of fentanyl domains 25 and 34, for HF-4 and HF-6, respectively.
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General strategy and coupling partners for the chemically contiguous series. aGeneral conditions fo...
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Vaccination, titer assessment, and bleed schedule.
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Summary of behavioral data for most promising chemically contiguous vaccine HF-7, compared to singu...
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Summary of behavioral data for phenethyl-linked haptens HF-4 and HF-6. Bars represent mean ± SEM.
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Correlation plots of dual hapten vaccines comparing week 5 and 8 ELISA midpoint titers to ED50 valu...
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Beilstein J. Org. Chem. 2019, 15, 1020–1031, doi:10.3762/bjoc.15.100
Design of potential antineoplastic nucleosides.
Synthesis of 4’-thioDMDC.
Synthesis of 4’-thioribonucleosides by Minakawa and Matsuda.
Synthesis of 4’-thioribonucleosides by Yoshimura.
Concept of the Pummerer-type glycosylation and hypervalent iodine-mediated glycosylation.
Oxidative glycosylation of 4-thioribose mediated by hypervalent iodine.
Speculated mechanism of oxidative glycosylation mediated by hypervalent iodine.
Synthesis of purine 4’-thioribonucleosides using hypervalent iodine-mediated glycosylation.
Unexpected glycosylation of a thietanose derivative.
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Speculated mechanism of the ring expansion of a thietanose derivative.
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Synthesis of thietanonucleosides using the Pummerer-type glycosylation.
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First synthesis of 4’-selenonucleosides.
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The Pummerer-type glycosylation of 4-selenoxide 74.
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Synthesis of purine 4’-selenonucleosides using hypervalent iodine-mediated glycosylation.
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Concept of the oxidative coupling reaction applicable to the synthesis of carbocyclic nucleosides.
Oxidative coupling reaction mediated by hypervalent iodine.
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Synthesis of cyclohexenyl nucleosides using an oxidative coupling reaction.
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Concept of the oxidative coupling reaction of glycal derivatives.
Oxidative coupling reaction of silylated uracil and DHP using hypervalent iodine.
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Proposed mechanism of the oxidative coupling reaction mediated by hypervalent iodine.
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Synthesis of 2’,3’-unsaturated nucleosides using hypervalent iodine and a co-catalyst.
Synthesis of dihydropyranonucleoside.
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Synthesis of acetoxyacetals using hypervalent iodine and addition of silylated base.
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One-pot fragmentation-nucleophilic additions mediated by hypervalent iodine.
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The reaction of thioglycoside with hypervalent iodine in the presence of Lewis acids.
Synthesis of disaccharides employing thioglycosides under an oxidative coupling reaction mediated b...
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Synthesis of disaccharides using disarmed thioglycosides by hypervalent iodine-mediated glycosylati...
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Glycosylation using aryl(trifluoroethyl)iodium triflimide.
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Expected mechanism of hypervalent iodine-mediated glycosylation with glycals.
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Synthesis of oligosaccharides by hypervalent iodine-mediated glycosylation with glycals.
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Synthesis of 2-deoxy amino acid glycosides.
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Rationale for the intramolecular migration of the amino acid unit.
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Beilstein J. Org. Chem. 2018, 14, 1595–1618, doi:10.3762/bjoc.14.137
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