/ Home
/ SUBMISSION

/ The BJOC
/ Diamond Open Access
/ Journal Statistics
/ Editorial Board
/ Community
/ Call for papers

/ Latest Articles
/ Most accessed
/ Thematic issues
/ Volumes
/ Authors

/ E-Alerts

/ TWITTER
/ LINKEDIN
/ Mastodon
/ RSS FEED

Empty search

Article Type

Publication Date Range

Search Tips

This search combines search strings from the content search (i.e. "Full Text", "Author", "Title", "Abstract", or "Keywords") with "Article Type" and "Publication Date Range" using the AND operator.

Search Examples

aromatic	the word “aromatic”
aromatic aldehyde	the word “aromatic” OR “aldehyde”
+aromatic +aldehyde	both words “aromatic” AND “aldehyde”
+aromatic -aldehyde	the word “aromatic” but NOT “aldehyde”
“aromatic aldehyde”	the exact phrase “aromatic aldehyde”
benz*	words which begin with “benz”, such as “benzene” or “benzyl”
benz*yl	words that begin with “benz” and end with “yl”, such as “benzyl” or “benzoyl”
benzyl~	words that are close to the word “benzyl”, such as “benzoyl” (i.e., fuzzy search)

BROWSE
Latest Articles
Most accessed
thematic issues
volumes
authors

BROWSE

Latest Articles Most Accessed Thematic Issues Volumes Authors

Author

Type 3 or more characters for results.

Type 2 or more characters for results.

Type 3 or more characters for results.

Type 2 or more characters for results.

2 article(s) from Nguyen, Nguyen Tran

4-(1-Methylamino)ethylidene-1,5-disubstituted pyrrolidine-2,3-diones: synthesis, anti-inflammatory effect and in silico approaches

Nguyen Tran Nguyen,
Vo Viet Dai,
Luc Van Meervelt,
Do Thi Thao and
Nguyen Minh Thong

Beilstein J. Org. Chem. 2025, 21, 817–829, doi:10.3762/bjoc.21.65

PDF

Graphical Abstract

Figure 1: Natural products and synthetic medicinal compounds containing a 2-pyrrolidinone subunit.

Jump to Figure 1

Scheme 1: Synthesis of 4-[1-(4-methoxybenzyl)amino]ethylidene-1,5-disubstituted pyrrolidine-2,3-diones 3a–e.

Jump to Scheme 1

Scheme 2: Synthesis of 4-(1-methylamino)ethylidene-1,5-disubstituted pyrrolidine-2,3-diones 5a–e.

Jump to Scheme 2

Scheme 3: Proposed mechanism for the reaction between 4-[1-(4-methoxybenzyl)amino]ethylidene-1,5-disubstitute...

Jump to Scheme 3

Figure 2: The molecular structure of 5a, showing the atom-labelling scheme and displacement ellipsoids at the...

Jump to Figure 2

Figure 3: The bioavailability radar of studied compounds 5a–e.

Jump to Figure 3

Figure 4: The interactions of potential drugs 5a–c in the active site of enzyme iNOS.

Jump to Figure 4

Figure 5: The interactions of potential drugs 5d and 5e and control drug (DEX) in the active site of enzyme i...

Jump to Figure 5

Album

Supp Info

Full Research Paper

Published 24 Apr 2025

Full text

Experimental and theoretical studies on the synthesis of 1,4,5-trisubstituted pyrrolidine-2,3-diones

Nguyen Tran Nguyen,
Vo Viet Dai,
Nguyen Ngoc Tri,
Luc Van Meervelt,
Nguyen Tien Trung and
Wim Dehaen

Beilstein J. Org. Chem. 2022, 18, 1140–1153, doi:10.3762/bjoc.18.118

PDF

Graphical Abstract

Figure 1: Structure of naturally occurring and synthetic 2-pyrrolidone derivatives.

Jump to Figure 1

Figure 2: Structure of natural compounds containing a 1,5-dihydro-2H-pyrrol-2-one subunit.

Jump to Figure 2

Scheme 1: Synthesis of substituted 4-acetyl-3-hydroxy-3-pyrroline-2-ones 4 via three-component reaction.

Jump to Scheme 1

Scheme 2: Proposed mechanistic path for the synthesis of substituted 4-acetyl-3-hydroxy-3-pyrroline-2-ones.

Jump to Scheme 2

Scheme 3: Tautomerism of compounds 4a–c in DMSO.

Jump to Scheme 3

Figure 3: View of the molecular structure of compound 10aa with atom labeling. Displacement ellipsoids are dr...

Jump to Figure 3

Figure 4: The PES of reaction for the synthesis of 1,4,5-trisubstituted pyrrolidine-2,3-dione 10ab enamine de...

Jump to Figure 4

Scheme 4: Reaction pathways from 4a, 4a’ to 10ab via IS5 in the gase phase.

Jump to Scheme 4

Scheme 5: Reaction pathways from 4a to 10ab-v2 via IS3 in the gase phase.

Jump to Scheme 5

Figure 5: The PES for the possible pathways (1), (2), (3), and (4) in ethanol solvent.

Jump to Figure 5

Figure 6: The optimized structures of some reactants, intermediates, transition states, and products in the p...

Jump to Figure 6

Album

Supp Info

Full Research Paper

Published 31 Aug 2022

Full text

Other Beilstein-Institut Open Science Activities

/ Help / Support & Contact / E-Alerts / Privacy Policy / Terms & Conditions / Impressum