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1 article(s) from Ramesh, Sunita A

Anti-invasive and cytotoxic evaluation of a (+)-pinoresinol-based semisynthetic library against glioblastoma

Chen Zhang,
Kah Yean Lum,
Jonathan M. White,
Paul I. Forster,
Nicholas Booth,
Sunita A. Ramesh and
Rohan A. Davis

Beilstein J. Org. Chem. 2026, 22, 691–704, doi:10.3762/bjoc.22.54

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Graphical Abstract

Figure 1: Chemical structures of the two known natural products, (+)-salicifoliol (1) and (+)-pinoresinol (2)...

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Figure 2: Reaction schemes detailing the semisynthesis of (+)-eudesmin (3), (+)-phillygenin (4), (+)-5,5'-dib...

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Figure 3: Key COSY, HMBC, and ROESY correlations for (+)-5,5'-dibromopinoresinol (5).

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Figure 4: ORTEP drawing of (+)-eudesmin (3).

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Figure 5: ECD data for compounds 2–7 in MeOH.

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Figure 6: Percentage of cell viability for (+)-pinoresinol (2) and its analogues (+)-eudesmin (3), (+)-philly...

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Figure 7: (A) Transwell invasive assay of the (+)-pinoresinol library 2–7 on U251MG cells at a concentration ...

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Figure 8: (A) Transwell invasion assay of (+)-4,4'-di(3,3-dimethylbutanoyl)pinoresinol (6) on KNS42 cells at ...

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Figure 9: The U251 cell line was derived from a grade III–IV malignant tumor, specifically an astrocytoma, ob...

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Published 11 May 2026

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