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Beilstein J. Org. Chem. 2026, 22, 1033–1047, doi:10.3762/bjoc.22.82
Graphical Abstract
Figure 1: General structure of isoxazoline, 1,2,4-oxadiazole and biologically active 1,2,4-oxadizole, isoxazo...
Scheme 1: Recent studies for the synthesis of 1,2,4-oxadiazole-isoxazoline hybrids.
Figure 2: Various adenosine receptor (AR) antagonists, catechol-O-methyltransferase (COMT) and 1,2,4-oxadiazo...
Scheme 2: Synthesis of novel 1,2,4-oxadiazole-isoxazoline lead compounds by 1,3-DC.
Scheme 3: Synthetic methods for accessing the starting compounds (2a–k, 6a–j). Reagents and conditions: a) NH2...
Scheme 4: Mechanism for the formation of novel 3,5-disubstituted 1,2,4-oxadiazolyl diarylisoxazolines 7a–ay (...
Figure 3: 3D and 2D binding interactions of best scoring compounds (7x-(S), 7x-(R), 7j-(S), 7aw-(S), 7aw-(R),...
Beilstein J. Org. Chem. 2018, 14, 3011–3017, doi:10.3762/bjoc.14.280
Figure 1: Synthesis of mono- or dialkylated acetonitriles.
Figure 2: Cyanation through 5-chloromethyl-3-(p-substituted-phenyl)-1,2,4-oxadiazole.
Figure 3: Expanded HSQC spectrum of 4a and 3a.
Figure 4: X-ray ORTEP plots of 3a and 4e.
Scheme 1: Plausible mechanism for the formation of 3.
Scheme 2: Plausible mechanism for the formation of 4 via decyanation of 3.