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Beilstein J. Org. Chem. 2025, 21, 2716–2729, doi:10.3762/bjoc.21.209
Graphical Abstract
Figure 1: Structures of bioactive molecules with trifluoromethylpyridine and piperidine frameworks.
Scheme 1: The reaction of ethyl trifluoroacetoacetate (1), acetone (2a) and 1,3- diaminopropan-2-ol (3).
Scheme 2: Three-component reaction of ethyl trifluoroacetoacetate (1), alkyl methyl ketones 2b,c and 1,3-diam...
Scheme 3: Three-component reaction of ethyl trifluoroacetoacetate (1), acetophenone (2d) and 1,3-diaminopropa...
Scheme 4: The proposed mechanism of three-component cyclization of 3-oxo ester 1, methyl ketones 2a–d and 1,3...
Figure 2: ORTEP view of compounds 4асc (a, CCDC: 2479553), 4аct (b, CCDC: 2479554), 4аtt (c, CCDC: 2479555), ...
Figure 3: ORTEP view of compound 5ctc (a, CCDC: 2479558), 5ctt (b, CCDC: 2479559) showing with the thermal el...
Figure 4: The fragments of the 1H NMR spectra (400 MHz, DMSO-d6) of diastereomers 4acc (a), 4аct (b), 4аtt (c...
Figure 5: Fragments of 1H NMR spectra (400 MHz, DMSO-d6) of hexahydrooxazolo[3,2-a]pyridin-5-ones 5ctc (a) an...