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3 article(s) from Sauer, Daniel F

Olefin metathesis catalysts embedded in β-barrel proteins: creating artificial metalloproteins for olefin metathesis

Daniel F. Sauer,
Johannes Schiffels,
Takashi Hayashi,
Ulrich Schwaneberg and
Jun Okuda

Review
Published 19 Nov 2018

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1. Graphical Abstract
2. Scheme 1: Left: Mechanism of the olefin metathesis reaction postulated by Chauvin [2]. Right: Potential influenc...
  
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3. Scheme 2: (i) Ring-opening metathesis polymerization (ROMP), (ii) ring-closing metathesis (RCM) and (iii) cro...
  
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4. Figure 1: Common anchoring strategies for metal-complex or metal ion incorporation into protein scaffolds.
  
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5. Scheme 3: Biotinylated GH-type catalysts for conjugation to (strept)avidin and their catalyzed ring-closing m...
  
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6. Scheme 4: Whole-cell artificial metatheases designed by Ward et al. [47].
  
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7. Scheme 5: Coupling of GH-type catalysts Ru-4/5/6 to NB4 or NB11.
  
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8. Scheme 6: Anchoring and refolding of GH-type catalysts Ru-4/5/6 to FhuA.
  
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9. Figure 2: Top: NB4 (PDB 3WJB); bottom: NB4exp. Highlighted in blue are the additional two β-sheets. Highlight...
  
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Graphical Abstract

Beilstein J. Org. Chem. 2018, 14, 2861–2871, doi:10.3762/bjoc.14.265

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2-Methyl-2,4-pentanediol (MPD) boosts as detergent-substitute the performance of ß-barrel hybrid catalyst for phenylacetylene polymerization

Julia Kinzel,
Daniel F. Sauer,
Marco Bocola,
Marcus Arlt,
Tayebeh Mirzaei Garakani,
Andreas Thiel,
Klaus Beckerle,
Tino Polen,
Jun Okuda and
Ulrich Schwaneberg

Full Research Paper
Published 31 Jul 2017

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1. Graphical Abstract
2. Figure 1: Phenylacetylene polymerization of FhuA ΔCVF^tev [29] refolded in a polymer or small amphiphilic molecule...
  
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3. Figure 2: Hydrophobic transmembrane region of FhuA ΔCVF^tev [29] stabilized by ≈200 MPD molecules. MPD is illustra...
  
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4. Scheme 1: Coupling of [Rh]-1 to the open channel protein FhuA ΔCVF^tev. SDS, sodium dodecyl sulfate; THF, tetr...
  
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5. Figure 3: Circular dichroism spectra of 2 refolded in 2-methyl-2,4-pentanediol (MPD, red) and polyethylene–po...
  
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6. Figure 4: MALDI–TOF mass spectra of apo FhuA ΔCVF^tev (red; calculated m/z = 5902.6; found: m/z = 5911.7) and 2...
  
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Graphical Abstract

Beilstein J. Org. Chem. 2017, 13, 1498–1506, doi:10.3762/bjoc.13.148

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Artificial Diels–Alderase based on the transmembrane protein FhuA

Hassan Osseili,
Daniel F. Sauer,
Klaus Beckerle,
Marcus Arlt,
Tomoki Himiyama,
Tino Polen,
Akira Onoda,
Ulrich Schwaneberg,
Takashi Hayashi and
Jun Okuda

Full Research Paper
Published 24 Jun 2016

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1. Graphical Abstract
2. Scheme 1: Syntheses to Cu(I) complex bearing a NHC ligand.
  
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3. Scheme 2: Synthesis of Cu(II) terpyridyl complexes.
  
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4. Scheme 3: Anchoring and refolding of the biohybrid copper complexes.
  
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5. Figure 1: CD spectra of refolded catalysts 17–19 (red: 17, black: 18, blue: 19).
  
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6. Figure 2: Temperature-dependent CD spectra of catalyst 17.
  
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7. Figure 3: MALDI–TOF mass spectra (black: 17, red: FhuAΔCVF^tev).
  
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Graphical Abstract

Beilstein J. Org. Chem. 2016, 12, 1314–1321, doi:10.3762/bjoc.12.124

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