1 article(s) from Shi, Xiaolin
The main three strategies of fluorination: nucleophilic, electrophilic and radical fluorination.
Jump to Scheme 1
Doyle’s Pd-catalyzed fluorination of allylic chlorides.
Jump to Scheme 2
Allylic fluorination of 2- and 3-substituted propenyl esters.
Jump to Scheme 3
Regioselective allylic fluorination of cinnamyl phosphorothioate esters.
Jump to Scheme 4
Palladium-catalyzed aliphatic C–H fluorination reported by Doyle.
Jump to Scheme 5
Pd-catalyzed enantioselective fluorination of α-ketoesters followed by stereoselective reduction to...
Jump to Scheme 6
Pd-catalyzed C(sp3)–H fluorination of oxindoles.
Jump to Scheme 7
C–H fluorination of 8-methylquinoline derivatives with F− reagents.
Jump to Scheme 8
Fluorination of α-cyano acetates reported by van Leeuwen.
Jump to Scheme 9
The catalytic enantioselective electrophilic C–H fluorination of α-chloro-β-keto phosphonates.
Jump to Scheme 10
Fluorination of unactivated C(sp3)–H bonds directed by the bidentate PIP auxiliary.
Jump to Scheme 11
Fluorination of C(sp3)–H bonds at the β-position of carboxylic acids.
Jump to Scheme 12
Enantioselective benzylic C–H fluorination with a chiral transient directing group.
Jump to Scheme 13
Microwave-heated Pd-catalyzed fluorination of aryl alcohols.
Jump to Scheme 14
Fluorination of aryl potassium trifluoroborates.
Jump to Scheme 15
C(sp2)–F bond formation using precatalyst [L·Pd]2(cod).
Jump to Scheme 16
Pd-catalyzed fluorination of (hetero)aryl triflates and bromides.
Jump to Scheme 17
The Pd-catalyzed C–H fluorination of arenes with Selectfluor/NFSI.
Jump to Scheme 18
Pd(II)-catalyzed ortho-monofluorination protocol for benzoic acids.
Jump to Scheme 19
Pd-catalyzed C(sp2)–H bond fluorination of 2-arylbenzothiazoles.
Jump to Scheme 20
Nitrate-promoted fluorination of aromatic and olefinic C(sp2)–H bonds and proposed mechanism.
Jump to Scheme 21
Fluorination of oxalyl amide-protected benzylamine derivatives.
Jump to Scheme 22
C–H fluorination of benzaldehydes with orthanilic acids as transient directing group.
Jump to Scheme 23
Pd(II)-catalyzed aryl C–H fluorination with various directing groups.
Jump to Scheme 24
Cu-catalyzed aliphatic, allylic, and benzylic fluorination.
Jump to Scheme 25
Cu-catalyzed SN2 fluorination of primary and secondary alkyl bromides.
Jump to Scheme 26
Copper-catalyzed fluorination of alkyl triflates.
Jump to Scheme 27
Cu-catalyzed fluorination of allylic bromides and chlorides.
Jump to Scheme 28
Synthetic strategy for the fluorination of active methylene compounds.
Jump to Scheme 29
Fluorination of β-ketoesters using a tartrate-derived bidentate bisoxazoline-Cu(II) complex.
Jump to Scheme 30
Highly enantioselective fluorination of β-ketoesters and N-Boc-oxindoles.
Jump to Scheme 31
Amide group-assisted site-selective fluorination of α-bromocarbonyl compounds.
Jump to Scheme 32
Cu-mediated aryl fluorination reported by Sanford .
Jump to Scheme 33
Mono- or difluorination reactions of benzoic acid derivatives.
Jump to Scheme 34
Cu-catalyzed fluorination of diaryliodonium salts with KF.
Jump to Scheme 35
Copper(I)-catalyzed cross-coupling of 2-pyridylaryl bromides.
Jump to Scheme 36
AgNO3-catalyzed decarboxylative fluorination of aliphatic carboxylic acids.
Jump to Scheme 37
The Mn-catalyzed aliphatic and benzylic C–H fluorination.
Jump to Scheme 38
Iron(II)-promoted C–H fluorination of benzylic substrates.
Jump to Scheme 39
Ag-catalyzed fluorodecarboxylation of carboxylic acids.
Jump to Scheme 40
Vanadium-catalyzed C(sp3)–H fluorination.
Jump to Scheme 41
AgNO3-catalyzed radical deboronofluorination of alkylboronates and boronic acids.
Jump to Scheme 42
Selective heterobenzylic C–H fluorination with Selectfluor reported by Van Humbeck.
Jump to Scheme 43
Fe(II)-catalyzed site-selective fluorination guided by an alkoxyl radical.
Jump to Scheme 44
Fluorination of allylic trichloroacetimidates reported by Nguyen et al.
Jump to Scheme 45
Iridium-catalyzed fluorination of allylic carbonates with TBAF(t-BuOH)4.
Jump to Scheme 46
Iridium-catalyzed asymmetric fluorination of allylic trichloroacetimidates.
Jump to Scheme 47
Cobalt-catalyzed α-fluorination of β-ketoesters.
Jump to Scheme 48
Nickel-catalyzed α-fluorination of various α-chloro-β-ketoesters.
Jump to Scheme 49
Ni(II)-catalyzed enantioselective fluorination of oxindoles and β-ketoesters.
Jump to Scheme 50
Scandium(III)-catalyzed asymmetric C–H fluorination of unprotected 3-substituted oxindoles.
Jump to Scheme 51
Iron-catalyzed directed C–H fluorination.
Jump to Scheme 52
Electrophilic silver-catalyzed Ar–F bond-forming reaction from arylstannanes.
Jump to Scheme 53
Nucleophilic, electrophilic and radical CF3 sources.
Jump to Figure 1
Cu(I)-catalyzed allylic trifluoromethylation of unactivated terminal olefins.
Jump to Scheme 54
Direct copper-catalyzed trifluoromethylation of allylsilanes.
Jump to Scheme 55
Cupper-catalyzed enantioselective trifluoromethylation of five and six-membered ring β-ketoesters.
Jump to Scheme 56
Cu-catalyzed highly stereoselective trifluoromethylation of secondary propargyl sulfonates.
Jump to Scheme 57
Remote C(sp3)–H trifluoromethylation of carboxamides and sulfonamides.
Jump to Scheme 58
Trifluoromethylation of allylsilanes with photoredox catalysis.
Jump to Scheme 59
Ag-catalyzed decarboxylative trifluoromethylation of aliphatic carboxylic acids in aqueous CH3CN.
Jump to Scheme 60
Decarboxylative trifluoromethylation of aliphatic carboxylic acids via combined photoredox and copp...
Jump to Scheme 61
Palladium-catalyzed Ar–CF3 bond-forming reaction.
Jump to Scheme 62
Palladium-catalyzed trifluoromethylation of arenes with diverse heterocyclic directing groups.
Jump to Scheme 63
Pd-catalyzed trifluoromethylation of indoles as reported by Liu.
Jump to Scheme 64
Pd-catalyzed trifluoromethylation of vinyl triflates and vinyl nonaflates.
Jump to Scheme 65
Pd(II)-catalyzed ortho-trifluoromethylation of aromatic C–H bonds.
Jump to Scheme 66
Visible-light-induced Pd(OAc)2-catalyzed ortho-trifluoromethylation of acetanilides with CF3SO2Na.
Jump to Scheme 67
CuI-catalyzed trifluoromethylation of aryl- and alkenylboronic acids.
Jump to Scheme 68
Cu-catalyzed trifluoromethylation of aryl- and vinylboronic acids.
Jump to Scheme 69
Copper-catalyzed trifluoromethylation of α,β-unsaturated carboxylic acids.
Jump to Scheme 70
Formation of C(sp2)–CF3 bond catalyzed by copper(I) complex.
Jump to Scheme 71
Loh’s Cu(I)-catalyzed trifluoromethylation of enamides and electron-deficient alkenes.
Jump to Scheme 72
Copper and iron-catalyzed decarboxylative tri- and difluoromethylation.
Jump to Scheme 73
Cu-catalyzed trifluoromethylation of hydrazones developed by Bouyssi.
Jump to Scheme 74
Cu(I)-catalyzed trifluoromethylation of terminal alkenes.
Jump to Scheme 75
Cu/Ag-catalyzed decarboxylative trifluoromethylation of cinnamic acids.
Jump to Scheme 76
Copper-catalyzed direct alkenyl C–H trifluoromethylation.
Jump to Scheme 77
Copper(I/II)-catalyzed direct trifluoromethylation of styrene derivatives.
Jump to Scheme 78
Regioselective trifluoromethylation of pivalamido arenes and heteroarenes.
Jump to Scheme 79
Synthesis of trifluoromethylquinones in the presence of copper(I).
Jump to Scheme 80
Oxidative trifluoromethylation of imidazoheterocycles in ionic liquid/water.
Jump to Scheme 81
A mild and fast continuous-flow trifluoromethylation of coumarins using a CuI/CF3SO2Na/TBHP system.
Jump to Scheme 82
Copper-catalyzed oxidative trifluoromethylation of various 8-aminoquinolines.
Jump to Scheme 83
PA-directed copper-catalyzed trifluoromethylation of anilines.
Jump to Scheme 84
Trifluoromethylation of potassium vinyltrifluoroborates catalyzed by Fe(II).
Jump to Scheme 85
Alkenyl trifluoromethylation catalyzed by Ru(phen)3Cl2 as photocatalyst.
Jump to Scheme 86
Ru-catalyzed trifluoromethylation of alkenes by Akita’s group.
Jump to Scheme 87
Ir-catalyzed Cvinyl–CF3 bond formation of α,β-unsaturated carboxylic acids.
Jump to Scheme 88
Ag(I)-catalyzed denitrative trifluoromethylation of β-nitrostyrenes.
Jump to Scheme 89
Photocatalyzed direct trifluoromethylation of aryl and heteroaryl C–H bonds.
Jump to Scheme 90
Rhenium (MTO)-catalyzed direct trifluoromethylation of aromatic substrates.
Jump to Scheme 91
Trifluoromethylation of unprotected anilines under [Ir(ppy)3] catalyst.
Jump to Scheme 92
Oxidative trifluoromethylation of imidazopyridines and imidazoheterocycles.
Jump to Scheme 93
Ruthenium-catalyzed trifluoromethylation of (hetero)arenes with trifluoroacetic anhydride.
Jump to Scheme 94
Phosphovanadomolybdic acid-catalyzed direct C–H trifluoromethylation.
Jump to Scheme 95
Picolinamide-assisted ortho-trifluoromethylation of arylamines.
Jump to Scheme 96
A nickel-catalyzed C–H trifluoromethylation of free anilines.
Jump to Scheme 97
Cu-mediated trifluoromethylation of terminal alkynes reported by Qing.
Jump to Scheme 98
Huang’s C(sp)–H trifluoromethylation using Togni’s reagent.
Jump to Scheme 99
Cu-catalyzed methods for trifluoromethylation with Umemoto’s reagent.
Jump to Scheme 100
The synthesis of alkynyl-CF3 compounds in the presence of fac-[Ir(ppy)3] under visible-light irradi...
Jump to Scheme 101
Pd-catalyzed Heck reaction reported by Reutrakul.
Jump to Scheme 102
Difluoromethylation of enamides and ene-carbamates.
Jump to Scheme 103
Difluoromethylation of α,β-unsaturated carboxylic acids.
Jump to Scheme 104
Copper-catalyzed direct C(sp2)–H difluoroacetylation reported by Pannecoucke and co-workers.
Jump to Scheme 105
Difluoroalkylation of aldehyde-derived hydrazones with functionalized difluoromethyl bromides.
Jump to Scheme 106
Photoredox-catalyzed C–H difluoroalkylation of aldehyde-derived hydrazones.
Jump to Scheme 107
Synergistic ruthenium(II)-catalyzed C–H difluoromethylation reported by Ackermann.
Jump to Scheme 108
Visible-light photocatalytic decarboxylation of α,β-unsaturated carboxylic acids.
Jump to Scheme 109
Synthesis of difluorinated ketones via S-alkyl dithiocarbamates obtained from acyl chlorides and po...
Jump to Scheme 110
Synthesis of aryl and heteroaryl difluoromethylated phosphonates.
Jump to Scheme 111
Difluoroalkylation of secondary propargyl sulfonates using Cu as the catalyst.
Jump to Scheme 112
Ru(II)-mediated para-selective difluoromethylation of anilides and their derivatives.
Jump to Scheme 113
Bulky diamine ligand promoted cross-coupling of difluoroalkyl bromides.
Jump to Scheme 114
Copper-catalyzed C3–H difluoroacetylation of quinoxalinones.
Jump to Scheme 115
Copper(I) chloride-catalyzed trifluoromethylthiolation of enamines, indoles and β-ketoesters.
Jump to Scheme 116
Copper-boxmi-catalyzed asymmetric trifluoromethylthiolation of β-ketoesters.
Jump to Scheme 117
Direct Cu-catalyzed trifluoromethylthiolation of boronic acids and alkynes.
Jump to Scheme 118
Cu-catalyzed synthesis of α-trifluoromethylthio-substituted ketones.
Jump to Scheme 119
Trifluoromethylthiolation reactions promoted by diazotriflone and copper.
Jump to Scheme 120
Halide activation of N-(trifluoromethylthio)phthalimide.
Jump to Scheme 121
The visible light-promoted trifluoromethylthiolation reported by Glorius.
Jump to Scheme 122
Synthesis of α-trifluoromethylthioesters via Goossen’s approach.
Jump to Scheme 123
Photoinduced trifluoromethylthiolation of diazonium salts.
Jump to Scheme 124
Ag-mediated trifluoromethoxylation of aryl stannanes and arylboronic acids.
Jump to Scheme 125
Catalytic (hetero)aryl C–H trifluoromethoxylation under visible light.
Jump to Scheme 126
Photoinduced C–H-bond trifluromethoxylation of (hetero)arenes.
Jump to Scheme 127
Beilstein J. Org. Chem. 2019, 15, 2213–2270, doi:10.3762/bjoc.15.218
Subscribe to our Latest Articles RSS Feed.
Register and get informed about new articles.
Follow the Beilstein-Institut