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Beilstein J. Org. Chem. 2026, 22, 897–904, doi:10.3762/bjoc.22.70
Graphical Abstract
Scheme 1: Reaction of 2-(diazoacetyl)-2H-azirines 1 with aldehydes 2.
Scheme 2: Reaction of 2-(diazoacetyl)-2H-azirine 1b with aldehyde 2b and the result of 2D NOESY experiment fo...
Scheme 3: Relative Gibbs free energies for the condensation of diazoacetylazirine 1a and benzaldehyde (2c) in...
Scheme 4: Plausible mechanism and relative Gibbs free energies for the acid-catalyzed transformation of the b...
Scheme 5: Synthesis of pyrroles 5. Isolated yield calculated for two synthetic steps based on azirine 1.
Scheme 6: Alkylation and triflation reactions of pyrrole 5a.
Beilstein J. Org. Chem. 2022, 18, 738–745, doi:10.3762/bjoc.18.74
Scheme 1: Approaches to the synthesis of alkyl 4-oxo-1,4-dihydropyridine-3-carboxylates.
Scheme 2: Synthesis of 4-oxo-1,4-dihydropyridine-3-carboxylates.
Scheme 3: Synthesis of Isoxazoles 11–13.
Scheme 4: Synthesis of isoxazoles 1.
Scheme 5: Synthesis of pyridones 2.
Scheme 6: Transformations of pyridones 2.