Towards allosteric receptors – synthesis of β-cyclodextrin-functionalised 2,2’-bipyridines and their metal complexes

• Christopher Kremer,
• Gregor Schnakenburg and
• Arne Lützen

Beilstein J. Org. Chem. 2014, 10, 814–824, doi:10.3762/bjoc.10.77

• ” is used by enzymes and proteins [6], which stands for cooperative effects in the binding of more than one substrate to different sites of a receptor. After binding of the first substrate (the effector), the receptor changes its conformation, and by this enhancing (positive allosteric cooperativity

• ) or hampering (negative allosteric cooperativity) the binding of another substrate at a second binding site. This powerful regulatory concept has become quite interesting in supramolecular chemistry, and the development of artificial receptor systems which can be controlled by allosteric effects comes

Spin state switching in iron coordination compounds

• Philipp Gütlich,
• Ana B. Gaspar and
• Yann Garcia

Beilstein J. Org. Chem. 2013, 9, 342–391, doi:10.3762/bjoc.9.39

• three synthetic strategies that have been developed to create and strengthen cooperativity, i.e., (i) incorporation of a hydrogen-bonded network; (ii) incorporation of π-stacking moieties; and (iii) coordination of bridging ligands. The thermal ST behavior is commonly expressed in terms of the molar