An improved synthesis of a fluorophosphonate–polyethylene glycol–biotin probe and its use against competitive substrates

• Hao Xu,
• Hairat Sabit,
• Gordon L. Amidon and
• H. D. Hollis Showalter

Beilstein J. Org. Chem. 2013, 9, 89–96, doi:10.3762/bjoc.9.12

• that hydrolyzes the ester group of enalapril and oseltamivir. Enalapril and oseltamivir are commercially available prodrugs, which are converted to enalaprilat and oseltamivir carboxylate, respectively, after being absorbed in the intestine. Carboxylesterase [22], a common esterase existing in multiple

Marilones A–C, phthalides from the sponge-derived fungus Stachylidium sp.

• Celso Almeida,
• Stefan Kehraus,
• Miguel Prudêncio and
• Gabriele M. König

Beilstein J. Org. Chem. 2011, 7, 1636–1642, doi:10.3762/bjoc.7.192

• , papain, porcine cease and acetylcholine esterase) were performed according to Neumann et al. [19]. Compounds were tested for protein kinase inhibition assays (DYRK1A and CDK5) according to Bettayeb et al. [20]. The triglyceride accumulation inhibition in the 3T3-L1 murine adipocytes assay was performed

Oxidative allylic rearrangement of cycloalkenols: Formal total synthesis of enantiomerically pure trisporic acid B

• Silke Dubberke,
• Muhammad Abbas and
• Bernhard Westermann

Beilstein J. Org. Chem. 2011, 7, 421–425, doi:10.3762/bjoc.7.54

• resolution; natural products; oxidative rearrangement; pig liver esterase (PLE); trisporic acid B; Introduction The generation of chiral, non-racemic compounds bearing a stereogenic quaternary carbon centre is of great interest [1][2][3][4][5][6][7][8]. Therefore, much effort has been directed towards the

• synthesis of this stereogenic unit and solutions have been found, e.g., by Christoffers and d’Angelo [9][10][11]. We have already disclosed our results to obtain these products highly enantiomerically enriched by pig liver esterase (PLE) catalyzed saponification of α-substituted β-ketoesters [12][13]. We

• -ketoester 1c, the racemate 1c is resolved by a pig liver esterase (PLE)-catalyzed saponification reaction. As in other cases reported earlier, the racemic β-ketoesters are hydrolyzed with high stereoselectivity allowing the isolation of optically pure esters (–)-1. The corresponding hydrolysis products, the

(Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties

• José L. Jiménez Blanco,
• Fernando Ortega-Caballero,
• Carmen Ortiz Mellet and
• José M. García Fernández

Beilstein J. Org. Chem. 2010, 6, No. 20, doi:10.3762/bjoc.6.20

• juvenile esterase gene as the target. The results showed that binding of a 20-mer DNG/DNA hexameric (ATATAT) chimera containing guanidinium linkages is more than 105.7 times stronger than the binding of the corresponding 20-mer of DNA. The hexameric DNG binds to DNA in a 1:1 ratio and is able to