Regioselective synthesis of 7,8-dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives: A new drug-like heterocyclic scaffold

• Nikolay T. Tzvetkov,
• Harald Euler and
• Christa E. Müller

Beilstein J. Org. Chem. 2012, 8, 1584–1593, doi:10.3762/bjoc.8.181

• therefore be developed for the treatment of haematological diseases, and inhibition of phosphodiesterase 10 (PDE10), which is potentially useful for the treatment of neurodegenerative diseases, especially Parkinson’s disease [11]. The scaffolds 1–4 consist of a 1,2,4-triazine core, which arises from the