Palladium- and copper-mediated N-aryl bond formation reactions for the synthesis of biological active compounds

• Carolin Fischer and
• Burkhard Koenig

Beilstein J. Org. Chem. 2011, 7, 59–74, doi:10.3762/bjoc.7.10

• )TMEDA]2Cl2, omitting the base and working at room temperature [13][14]. Besides palladium and copper, nickel catalysis also allows the arylation of primary and secondary amines [15][16]. However, the three methods (Ullmann–Goldberg, Buchwald–Hartwig and Chan–Lam) have become standard procedures for N