Synthesis of diverse indole libraries on polystyrene resin – Scope and limitations of an organometallic reaction on solid supports

• Kerstin Knepper,
• Sylvia Vanderheiden and
• Stefan Bräse

Beilstein J. Org. Chem. 2012, 8, 1191–1199, doi:10.3762/bjoc.8.132

• benzoic acids on Merrifield resin: In a three-necked round-bottom flask equipped with a mechanical stirrer, 5 equiv of cesium carbonate are suspended in DMF (mL/mmol) and are stirred for 30 min at 50 °C. Next, 5 equiv of benzoic acid are added and the mixture is stirred for another 30 min. Afterwards, one

Identification and synthesis of impurities formed during sertindole preparation

• I. V. Sunil Kumar,
• G. S. R. Anjaneyulu and
• V. Hima Bindu

Beilstein J. Org. Chem. 2011, 7, 29–33, doi:10.3762/bjoc.7.5

• -bromo-4-fluorobenzene (12), formation of traces of 5-chloro-1-(4-bromophenyl) indole (18) along with the desired indole 13 was observed. A detail study of this coupling reaction revealed significant formation of this undesired indole in the absence of a transition metal, especially when cesium carbonate

Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups

• Julien Rolland,
• Xacobe C. Cambeiro,
• Carles Rodríguez-Escrich and
• Miquel A. Pericàs

Beilstein J. Org. Chem. 2009, 5, No. 56, doi:10.3762/bjoc.5.56

• stereospecific ring-opening with piperazine, and the resulting diamino alcohol 3 is subsequently supported onto a slightly cross-linked (1% DVB) Merrifield resin by direct treatment at room temperature in DMF in the presence of cesium carbonate (Scheme 3). Evaluation of resin 2 under batch conditions Prior to

Novel banana-discotic hybrid architectures

• Hari Krishna Bisoyi,
• H. T. Srinivasa and
• Sandeep Kumar

Beilstein J. Org. Chem. 2009, 5, No. 52, doi:10.3762/bjoc.5.52

• triphenylene (2.0 g, 2.7 mmol), 1,12-dibromododecane (4.4 g, 13.0 mmol), cesium carbonate (1.12 g, 8.8 mmol) and 50 ml of methyl ethyl ketone (MEK) was refluxed for 48 h at 85 °C. The resulting mixture was cooled and poured into 50 ml of water and then extracted into chloroform. The organic layer was washed

• . Preparation of benzyl 4-{12-[3,6,7,10,11-pentakis(hexyloxy)triphenylene-2-yloxy]dodecyloxy}benzoate (3): Triphenylene bromide 2 (2.34 g, 2.3 mmol), benzyl 4-hydroxy benzoate (0.45 g, 1.98 mmol) and cesium carbonate (2.0 g, 5.94 mmol) in 50 mL of MEK was refluxed for 48 h. The reaction mixture was poured into