Fused bicyclic piperidines and dihydropyridines by dearomatising cyclisation of the enolates of nicotinyl-substituted esters and ketones

• Heloise Brice,
• Jonathan Clayden and
• Stuart D. Hamilton

Beilstein J. Org. Chem. 2010, 6, No. 22, doi:10.3762/bjoc.6.22

• %, MNH4+); (Found: MH+, 258.1340. C12H19NO5 requires MH+, 258.1336). Coupling constants (Hz) in the major diastereoisomer of 15. Determination of the stereochemistry of 20b. Arrows indicate nuclear Overhauser enhancements. Dearomatising cyclisations (a) of enolates; (b) of electron-rich heteroaromatics