Synthesis of fluorinated δ-lactams via cycloisomerization of gem-difluoropropargyl amides

• Satoru Arimitsu and
• Gerald B. Hammond

Beilstein J. Org. Chem. 2010, 6, No. 48, doi:10.3762/bjoc.6.48

• reaction time. The stereochemistry of 7a and 7b was determined by COSY and NOESY experiments. Recently, various tandem reactions with ruthenium complexes have become popular in organic chemistry because Ru(II) complexes are capable of catalyzing additional reactions [26][27]. Since our enyne metathesis

• (Scheme 3). In summary, gem-difluoro-1,7-enyne carbonyl derivatives are useful reaction partners in enyne metathesis cycloisomerization and CM–EYM tandem reactions catalyzed by ruthenium carbene complexes. The resulting diene products can be elaborated further using a Diels–Alder reaction. Comparison of

Prins fluorination cyclisations: Preparation of 4-fluoro-pyran and -piperidine heterocycles

• Guillaume G. Launay,
• Alexandra M. Z. Slawin and
• David O'Hagan

Beilstein J. Org. Chem. 2010, 6, No. 41, doi:10.3762/bjoc.6.41

• in the products, differing only in the orientation of the fluorine. In general, these reactions gave good diastereoselectivities in moderate to good yields (Scheme 3). Aza-Prins fluorination reaction The aza-Prins reaction is less well known but has been exploited, e.g., in tandem reactions in

Solvent-free phase-vanishing reactions with PTFE (Teflon^®) as a phase screen

• Kevin Pels and
• Veljko Dragojlovic

Beilstein J. Org. Chem. 2009, 5, No. 75, doi:10.3762/bjoc.5.75

• a very good yield (Table 3, entry 2). Bromination of 3-butenoic acid (21) gave the corresponding lactone 22 as the minor product while the dibromoacid 23 was the major product. We examined the possibility of tandem reactions with a solvent-free Diels-Alder/halolactonization reaction. Cyclopentadiene

Radical cascades using enantioenriched 7-azabenzonorbornenes and their applications in synthesis

• David M. Hodgson and
• Leonard H. Winning

Beilstein J. Org. Chem. 2008, 4, No. 38, doi:10.3762/bjoc.4.38

• -azabenzonorbornadienes. Oxidation (using RuO4) and Birch reduction of the 2-aza-5,6-benzonorbornenes provide access to substituted pyrrolidines and tetrahydroindenes, respectively. Keywords: asymmetric synthesis; deoxygenation; radicals; rearrangements; tandem reactions; Introduction Carbon-centred radicals have been

Combining two-directional synthesis and tandem reactions, part 11: second generation syntheses of (±)-hippodamine and (±)-epi-hippodamine

• Annabella F. Newton,
• Martin Rejzek,
• Marie-Lyne Alcaraz and
• Robert A. Stockman

Beilstein J. Org. Chem. 2008, 4, No. 4, doi:10.1186/1860-5397-4-4