Perhalogenated pyrimidine scaffolds. Reactions of 5-chloro- 2,4,6-trifluoropyrimidine with nitrogen centred nucleophiles

• Emma L. Parks,
• Graham Sandford,
• John A. Christopher and
• David D. Miller

Beilstein J. Org. Chem. 2008, 4, No. 22, doi:10.3762/bjoc.4.22

• desirable process but one of the most difficult to achieve in practice. Pyrimidines are electron-deficient aromatic systems and, when halogenated, become very useful substrates for a variety of nucleophilic aromatic substitution (SNAr) processes [9] and, since numerous chloropyrimidines are commercially