Colchitaxel, a coupled compound made from microtubule inhibitors colchicine and paclitaxel

• Karunananda Bombuwala,
• Thomas Kinstle,
• Vladimir Popik,
• Sonal O. Uppal,
• James B. Olesen,
• Jose Viña and
• Carol A. Heckman

Beilstein J. Org. Chem. 2006, 2, No. 13, doi:10.1186/1860-5397-2-13

• , is essential for microtubule binding activity, as change of the keto group to a thioketo group or demethylation of the OMe group in this ring reduced the activity [31](reviewed in [2]). Demethylation of the OMe group in ring A also decreased the activity, indicating the importance of this ring for