8-epi-Salvinorin B: crystal structure and affinity at the κ opioid receptor

• Thomas A. Munro,
• Katharine K. Duncan,
• Richard J. Staples,
• Wei Xu,
• Lee-Yuan Liu-Chen,
• Cécile Béguin,
• William A. Carlezon Jr. and
• Bruce M. Cohen

Beilstein J. Org. Chem. 2007, 3, No. 1, doi:10.1186/1860-5397-3-1

• later identified the byproduct mentioned above as 8-epi-diol 3.[15] Characterization data was given, but the basis of the structure assignment was not stated. The first structure elucidation of one of these compounds was of 8-epi-salvinorin A (1b).[16] The trans-diaxial H-8 coupling constant found in

Diastereoselective synthesis of some novel benzopyranopyridine derivatives

• Pradeep K. Mohakhud,
• Sujeet M. R. Kumar,
• Vasanth M. R. Kumar,
• Ravi M. R. Kumar,
• Moses D. R. Babu,
• Vyas D. R. K and
• Om D. R. Reddy

Beilstein J. Org. Chem. 2006, 2, No. 25, doi:10.1186/1860-5397-2-25

• determined as S,S by X-ray diffraction analysis (Figure 4) (For details see also: Figure 4 and Supporting Information File 1). Structure elucidation of 5b The mass spectrum of 5b displayed a molecular ion at m/z 245 corresponding to the molecular formula C14H15NO3. Interestingly the molecular ion is 18 amu

An efficient synthesis of tetramic acid derivatives with extended conjugation from L-Ascorbic Acid

• Biswajit K. Singh,
• Surendra S. Bisht and
• Rama P. Tripathi

Beilstein J. Org. Chem. 2006, 2, No. 24, doi:10.1186/1860-5397-2-24

• consists of reaction of the above dienyl tetronic acids with different amines separately to form the required intermediate 5-hydroxy tetramic acid derivatives. Thus reaction of 9 first with ethanolic ammonia led to the formation of 5-hydroxy lactam derivative 11 in good yield. The structure elucidation of