Oxidative cyclization of alkenols with Oxone using a miniflow reactor

• Yoichi M. A. Yamada,
• Kaoru Torii and
• Yasuhiro Uozumi

Beilstein J. Org. Chem. 2009, 5, No. 18, doi:10.3762/bjoc.5.18

• inexpensive oxidant for this transformation [35][36][37][38][39][40][41][42], Oxone however is also a known fire and explosion hazard [43] essentially rendering its large-scale use impractical. To avoid these potentially dangerous and hazardous conditions in a large-scale batch oxidation, we switched the

An improved synthesis of 1,3,5-triaryl- 2-pyrazolines in acetic acid aqueous solution under ultrasound irradiation

• Ji-Tai Li,
• Xiao-Hui Zhang and
• Zhi-Ping Lin

Beilstein J. Org. Chem. 2007, 3, No. 13, doi:10.1186/1860-5397-3-13

• organic synthesis in that new reaction conditions need to be found which reduce the emission of volatile organic solvents and the use of hazardous toxic chemicals. Organic reactions in aqueous media have attracted increasing interest currently because of environmental issues and the understanding of

EcoScale, a semi- quantitative tool to select an organic preparation based on economical and ecological parameters

• Koen Van Aken,
• Lucjan Strekowski and
• Luc Patiny

Beilstein J. Org. Chem. 2006, 2, No. 3, doi:10.1186/1860-5397-2-3

• not take into account the nature and environmental impact of the generated waste. In order to arrive at a more meaningful prediction, the E-factor is multiplied by a environmentally hazardous quotient Q. For example, a Q value of 1 can be attributed to NaCl, while heavy metals can be assigned a value

• new products are fully characterized. Finally, one should never forget that the combination of certain individual compounds can create a hazardous situation (e.g. exothermic reaction between acids and bases). For assessing these hazards, a wide variety of information is readily available, such as the