A review of new developments in the Friedel–Crafts alkylation – From green chemistry to asymmetric catalysis

• Magnus Rueping and
• Boris J. Nachtsheim

Beilstein J. Org. Chem. 2010, 6, No. 6, doi:10.3762/bjoc.6.6

• , only highly reactive ferrocenyl alcohols 29a or benzhydrols 29b–d, which result in highly stabilized carbocations upon elimination, can be used in this procedure (Scheme 13) [50]. An interesting domino reduction–alkylation procedure was recently developed by Peris et al. employing a versatile Ir-Cp

Mitomycins syntheses: a recent update

• Jean-Christophe Andrez

Beilstein J. Org. Chem. 2009, 5, No. 33, doi:10.3762/bjoc.5.33

• ) [114]. 5.4. Parson. Radical cyclization The development of novel cascade (or domino) radical reactions is an active area of current research, and one approach to the mitomycin ring system focused on the application of 1-6-hydrogen atom transfer to create a pyrrolidinone radical, which could then

Synthesis of (–)-Indolizidine 167B based on domino hydroformylation/cyclization reactions

• Giuditta Guazzelli,
• Raffaello Lazzaroni and
• Roberta Settambolo

Beilstein J. Org. Chem. 2008, 4, No. 2, doi:10.1186/1860-5397-4-2

• multi-step domino reaction sequences which are a very convenient approach to complex architectures in one simple, safe, environmentally acceptable and resource-effective operation [12][13][14]. The mechanistic as well as synthetic implications of the oxo reaction involving vinyl and allyl aromatic and

• heteroaromatic olefins has a topic of our research for many years [15][16][17][18][19]; now it is the first time that the rhodium catalyzed hydroformylation is employed by us in the total synthesis of a target compound and as a key reaction in a domino process with a high number of steps. Results and Discussion

• describe here a new synthesis of optically active (–)-Indolizidine 167B based on regioselective hydroformylation/intramolecular cyclization reactions which provides a general approach to the indolizine nucleus. It is a multi-step domino process which starts with the interconversion of the isomeric rhodium

Desymmetrization of 7-azabicycloalkenes by tandem olefin metathesis for the preparation of natural product scaffolds

• Wolfgang Maison,
• Marina Büchert and
• Nina Deppermann

Beilstein J. Org. Chem. 2007, 3, No. 48, doi:10.1186/1860-5397-3-48

• RORCM conversions, because they may be desymmetrized either by diastereoselective or enantioselective metathesis. Results and Discussion In a first attempt to transfer the RORCM-strategy to 7-azabicycloalkenes, we chose 7 as a precursor for domino metathesis reactions. Our choice was due to the

An efficient synthesis of novel pyrano[2,3-d]- and furopyrano[2,3-d]pyrimidines via indium- catalyzed multi- component domino reaction

• Dipak Prajapati and
• Mukut Gohain

Beilstein J. Org. Chem. 2006, 2, No. 11, doi:10.1186/1860-5397-2-11

• Dipak Prajapati Mukut Gohain Department of Medicinal Chemistry, Regional Research Laboratory, Jorhat 785006, Assam, India 10.1186/1860-5397-2-11 Abstract Various novel pyrano [2,3-d]pyrimidines 5 and furopyrano [2,3-d]pyrimidines 7 were synthesized in 80–99% yields via a multicomponent domino

• reaction of α,β-ethylenic ketones and ethyl vinyl ether or 2,3-dihydrofuran has remained unexplored.[11] Herein, we report the first example of indium(III) chloride catalysed synthesis of fused pyrimidine derivatives via a multicomponent domino Knoevenagel hetero Diels-Alder reaction. The reaction proceeds

• comparable yields. The structure of all the products thus obtained were characterized by elemental and spectral analyses. Conclusion In conclusion, we have shown that the multicomponent domino Knoevenagel condensation/hetero-Diels-Alder reaction of aromatic aldehydes with 1,3-dimethylbarbituric acid and