Synthesis of 2,6-trans- disubstituted 5,6-dihydropyrans from (Z)-1,5-syn-endiols

• Eric M. Flamme and
• William R. Roush

Beilstein J. Org. Chem. 2005, 1, No. 7, doi:10.1186/1860-5397-1-7

• -dihydropyrans. Furthermore, there are only limited reports describing the stereoselective synthesis of related tetrahydropyrans through cyclodehydration of enantiopure 1,5-diols substrates.[17] The challenge of synthesizing dihydropyrans 3 or ent-3 from 1,5-diols such as 2 lies in the differentiation of the two