Reactions of acryl thioamides with iminoiodinanes as a one-step synthesis of N-sulfonyl-2,3-dihydro-1,2-thiazoles

• Vladimir G. Ilkin,
• Pavel S. Silaichev,
• Valeriy O. Filimonov,
• Tetyana V. Beryozkina,
• Margarita D. Likhacheva,
• Pavel A. Slepukhin,
• Wim Dehaen and
• Vasiliy A. Bakulev

Beilstein J. Org. Chem. 2025, 21, 1397–1403, doi:10.3762/bjoc.21.104

• groups; synthesis; 1,2-thiazolines; thioamides; Introduction 1,2-Thiazoles (isothiazoles) exhibit a wide range of biological activity (Figure 1): antipoliovirus [1], anticancer [2][3][4][5][6][7], against Parkinson's disease [8], and diabetes [9][10][11], and are also used as microbiocides [12][13