Beilstein J. Org. Chem.2013,9, 265–269, doi:10.3762/bjoc.9.32
configurations of these new chiral 10-heteroazatriquinanes are confirmed by X-ray single-crystal diffraction analysis.
Keywords: cis-2,5-disubstituted pyrrolidine; 10-heteroazatriquinane; tandem cyclization; X-ray single-crystal diffraction analysis; Introduction
The azatriquinane derivatives are an important
, this 10-heteroazatriquinane 7b possesses a rigid bowl-like molecular scaffold with a quaternary nitrogen site (N2) at the bottom of the cavity. Recently, Denmark and colleagues [25][26] have synthesized a series of chiral phase-transfer catalysts (chiral PTCs) based on a 2-azatriquinane skeleton
][13][14] from compounds 4 through three steps, including reduction, debenzylation and cyclization (Scheme 1), but this failed. However, we have found a novel one-pot tandem cyclization of these enantiopure asymmetric cis-2,5-disubstituted pyrrolidines to produce chiral trisubstituted 10
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Graphical Abstract
Figure 1:
The structures of azatriquinanes and azatriquinacene.