Beilstein J. Org. Chem.2019,15, 769–779, doi:10.3762/bjoc.15.73
synthesis of 2-vinylbenzylamines is reported. This involves obtaining 2-vinylbenzylamine ligands from tetrahydroisoquinoline by alkylation and reduction followed by the Hofmann cleavage. The resultant 2-vinylbenzylamines allowed us to obtain new Hoveyda–Grubbs catalysts, which were thoroughly characterised
; cross metathesis; Hoveyda–Grubbs catalyst; olefin metathesis; RCM; ring-closing metathesis; ring-opening cross metathesis; ROCM; ruthenium metathesis catalyst; styrene; 2-vinylbenzylamine; Introduction
Ruthenium-catalysed olefin metathesis reactions have been playing an important role in various fields
of studies by our group, which will be devoted to the synthesis and reactivity of Hoveyda–Grubbs-type catalysts possessing a six-membered ruthenium-containing ring with the N→Ru, S→Ru, and Se (Te)→Ru coordinate bonds.
Results and Discussion
2-Vinylbenzylamine synthesis
The assembly of the nitrogen
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Graphical Abstract
Figure 1:
Commercially available ruthenium catalysts for metathesis reactions.