Beilstein J. Org. Chem.2024,20, 205–211, doi:10.3762/bjoc.20.20
excellent yield and enantioselectivity.
Keywords: asymmetric organocatalysis; chiral Brønsted acid; 3,3-difluoroindoline; Hantzsch ester; transfer hydrogenation; Introduction
The introduction of fluoro atoms into organic molecules can alter their lipophilicity, solubility, metabolic stability, and
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Graphical Abstract
Figure 1:
Structures of bioactive fluorinated indole derivatives.