Beilstein J. Org. Chem.2021,17, 2321–2328, doi:10.3762/bjoc.17.150
-substituted oxindole intermediates and SN1 reactions with haloid acids. This new procedure features mild reaction conditions, simple operation, good yield, readily available and inexpensive starting materials, and gram-scalability.
Keywords: acidolysis; haloid acids; isatin; 3-monohalooxindole; 3-phosphate
-substituted oxindoles; Introduction
3-Monohalooxindole heterocycles are not only present as a characteristic structural motif in numerous biological and medicinal molecules [1][2] but also possess dual nucleophilic and electrophilic character at the C-3 position. Owing to the dual nature at the C-3 position
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Graphical Abstract
Figure 1:
Representation of bioactive molecules and applications.