Versatile synthesis and biological evaluation of novel 3’-fluorinated purine nucleosides

• Hang Ren,
• Haoyun An,
• Paul J. Hatala,
• William C. Stevens Jr,
• Jingchao Tao and
• Baicheng He

Beilstein J. Org. Chem. 2015, 11, 2509–2520, doi:10.3762/bjoc.11.272

• potent tumor cell growth inhibition activity at sub- or low micromolar concentration. Keywords: anticancer; 3’-fluororibonucleoside; purine nucleoside; 6-substituted purine; synthesis; Introduction Antimetabolites are extremely useful for the treatment of cancers and viral infections and are one of the