β-Lactamase inhibition profile of new amidine-substituted diazabicyclooctanes

• Zafar Iqbal,
• Lijuan Zhai,
• Yuanyu Gao,
• Dong Tang,
• Xueqin Ma,
• Jinbo Ji,
• Jian Sun,
• Jingwen Ji,
• Yuanbai Liu,
• Rui Jiang,
• Yangxiu Mu,
• Lili He,
• Haikang Yang and
• Zhixiang Yang

Beilstein J. Org. Chem. 2021, 17, 711–718, doi:10.3762/bjoc.17.60

• derivative B22 which was treated with tetrabutylammonium fluoride (TBAF) in THF to obtain the hydroxy derivative C22. Compound C22 was converted to the sodium salt of A22 by using the procedure described for derivative A1. Analogously, compound A23 was prepared starting from 4-aminothiazole-2-carboxylic acid

Synthesis and enzymatic evaluation of 2- and 4-aminothiazole- based inhibitors of neuronal nitric oxide synthase

• Graham R. Lawton,
• Haitao Ji,
• Pavel Martásek,
• Linda J. Roman and
• Richard B. Silverman

Beilstein J. Org. Chem. 2009, 5, No. 28, doi:10.3762/bjoc.5.28

• a 2-aminopyridine group were recently designed and synthesized in our laboratory and were shown to have significant in vivo efficacy. In this work, analogs of our lead compound possessing 2- and 4-aminothiazole rings in place of the aminopyridine were synthesized. The less basic aminothiazole rings

• potent than the 2-aminopyridine-based analogue. 4-Aminothiazoles were unstable in water, undergoing tautomerization and hydrolysis to give inactive thiazolones. Keywords: 2-aminothiazole; 4-aminothiazole; nitric oxide synthase inhibitor; nNOS; Introduction Neuronal nitric oxide synthase (nNOS) is the

• followed by removal of the Boc groups (Scheme 5). Although the final deprotection did give the desired product, as evidenced by mass spectrometry, on addition of water, the product decomposed. The 4-aminothiazole tautomerized to the thiazoline, which was then hydrolyzed [20]. Test reactions on model 4