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Search for "C–H bromination" in Full Text gives 4 result(s) in Beilstein Journal of Organic Chemistry.

Recent advances in amidyl radical-mediated photocatalytic direct intermolecular hydrogen atom transfer

  • Hao-Sen Wang,
  • Lin Li,
  • Xin Chen,
  • Jian-Li Wu,
  • Kai Sun,
  • Xiao-Lan Chen,
  • Ling-Bo Qu and
  • Bing Yu

Beilstein J. Org. Chem. 2025, 21, 1306–1323, doi:10.3762/bjoc.21.100

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  • radicals, while halogenation was promoted by the introduced halogen atom [26]. In 2014, Alexanian’s group reported a site-selective aliphatic CH bromination utilizing modified HRP as both the bromination reagent and HAT reagent (Scheme 11) [25]. Initiated by visible light, HRP-10 underwent homolytic
  • that regenerated amidyl radical 45. This system effectively examined the site selectivity of aliphatic CH bromination, yielding products 80–82, and 83 with 54% to 63% yields at selective positions. This bromination system provided a mild reaction environment suitable for aliphatic C–H bonds. In 2016
  • carbanion, which undergoes either solvent-mediated protonation or direct proton transfer from the acridiniumamide, ultimately delivering product 89 while regenerating the zwitterionic HRP-12 catalyst. This catalytic platform demonstrated exceptional site selectivity in aliphatic CH bromination under
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Published 27 Jun 2025

(Bio)isosteres of ortho- and meta-substituted benzenes

  • H. Erik Diepers and
  • Johannes C. L. Walker

Beilstein J. Org. Chem. 2024, 20, 859–890, doi:10.3762/bjoc.20.78

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Published 19 Apr 2024

Copper-promoted C5-selective bromination of 8-aminoquinoline amides with alkyl bromides

  • Changdong Shao,
  • Chen Ma,
  • Li Li,
  • Jingyi Liu,
  • Yanan Shen,
  • Chen Chen,
  • Qionglin Yang,
  • Tianyi Xu,
  • Zhengsong Hu,
  • Yuhe Kan and
  • Tingting Zhang

Beilstein J. Org. Chem. 2024, 20, 155–161, doi:10.3762/bjoc.20.14

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  • , employing activated and unactivated alkyl bromides as the halogenation reagents without additional external oxidants. This method features outstanding site selectivity, broad substrate scope, and excellent yields. Keywords: aminoquinolines; CH bromination; copper catalysis; regioselectivity; Introduction
  • quinoline ring of 1a in this reaction. Other competitive site-selective CH bromination products and multiple brominated products were not observed. Subsequently, the bromination reaction was examined with various catalysts such as CoCl2·6H2O, Ni(OAc)2·4H2O, MnSO4·H2O, CuCl, CuBr, CuCl2, CuBr2, and Cu(OAc)2
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Published 23 Jan 2024

C–H bond halogenation catalyzed or mediated by copper: an overview

  • Wenyan Hao and
  • Yunyun Liu

Beilstein J. Org. Chem. 2015, 11, 2132–2144, doi:10.3762/bjoc.11.230

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  • acquired as dibromoanilines via double CH bromination process. On the other hand, the chlorination was found less effective due to the presence of the side transformation and formation of N-acetylated byproducts [50]. In 2009, Stahl et al. [51] reported a Cu-catalyzed aerobic C–H halogenation protocol of
  • -catalyzed arene C–H fluorination of benzamides. Copper-catalyzed arene C–H iodination of 1,3-azoles. Copper-catalyzed C–H halogenations of phenols. Proposed mechanism for the C–H halogenation of phenols. Copper-catalyzed halogenation of electron enriched arenes. Copper-catalyzed CH bromination of arenes
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Published 09 Nov 2015
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