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Search for "CD4" in Full Text gives 8 result(s) in Beilstein Journal of Organic Chemistry.
N-tert-Butanesulfinyl imines in the asymmetric synthesis of nitrogen-containing heterocycles
Beilstein J. Org. Chem. 2021, 17, 1096–1140, doi:10.3762/bjoc.17.86
- alkaloids that were isolated in the mid-1990s from the Caribbean sponge bataella sp. From a biological point of view, the batzelladines have received attention due to their reported activity as inhibitors of HIV gp120-human CD4 binding. Chiral N-tert-butanesulfinyl aldimine (SS)-58 was used as a precursor
Enhanced target cell specificity and uptake of lipid nanoparticles using RNA aptamers and peptides
Beilstein J. Org. Chem. 2021, 17, 891–907, doi:10.3762/bjoc.17.75
- potential of compounds [43]. To assess the specific uptake of the G-3 aptamer, we used TZM-bLs. TZM-bL is a HeLa-derived cell line that was engineered to express CD4 and CCR5 receptors on the cell surface [44]. HeLa cells were used as a negative control. To investigate the specific uptake of the A-1 aptamer
- complexation with cluster of differentiation 4 (CD4) and CCR5 or C-X-C motif chemokine receptor 4 (CXCR4) host cell surface receptors [35]. As such, gp160 expression on the host cell surface receptor may not be as adept at facilitating cell entry via receptor-mediated endocytosis. Although in 2009, Zhou et al
What contributes to an effective mannose recognition domain?
Beilstein J. Org. Chem. 2017, 13, 2584–2595, doi:10.3762/bjoc.13.255
- host immune attack. Thus, DC-SIGN plays a key role in the dissemination of HIV-1 by capturing of HIV-1 at entry sites of infection and subsequent transport of the virus to CD4+ T cells in lymphoid tissues. The weak monovalent binding affinity of DC-SIGN (E) is compensated for by a multivalent display
The chemistry and biology of mycolactones
Beilstein J. Org. Chem. 2017, 13, 1596–1660, doi:10.3762/bjoc.13.159
Effects of RAMEA-complexed polyunsaturated fatty acids on the response of human dendritic cells to inflammatory signals
Beilstein J. Org. Chem. 2014, 10, 3152–3160, doi:10.3762/bjoc.10.332
- activated moDCs play a crucial role in the polarization of naïve CD4+ T-lymphocytes toward inflammatory or tolerogenic directions. Previous studies demonstrated that n−3 PUFAs have the potential to decrease the production of both cytokines [11][12]. To assess the effects of n−3 PUFAs on the expression of IL
Glycosystems in nanotechnology: Gold glyconanoparticles as carrier for anti-HIV prodrugs
Beilstein J. Org. Chem. 2014, 10, 1339–1346, doi:10.3762/bjoc.10.136
- virus type-1 (HIV-1) [1] continues to be a major leading pandemic disease worldwide with approximately 34 million people living with HIV [2]. Due to its incredible genetic variance and the specificity for CD4+ T cells, this virus is responsible for 800.000 deaths per year. In addition to sexual
- preventions, the strategies used to inhibit viral replication in human CD4+ T cells consist in the highly active antiretroviral therapy (HAART) [3] and the design of a vaccine that should protect people among all the different HIV strains [4][5]. Although great results have been obtained by the use of the
- . Some of these nanomaterials like polymeric nanoparticles, lipid nanoparticles and nanofibers have shown the ability to improve solubility, stability and permeability of anti-HIV drugs [9][10], but also to reduce the viral load by the activation of latently infected CD4+ T-cells [11]. Gold nanoparticles
Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimetic
Beilstein J. Org. Chem. 2014, 10, 1317–1324, doi:10.3762/bjoc.10.133
- targets for antigen delivery and therapeutic vaccination against cancer [9][10]. Several approaches have been investigated to pulse DCs with target antigens with the aim to induce robust and long-lasting CD4+ and CD8+ T cell responses against tumors [9][10]. In general, the first step of DC vaccination
- immediately analyzed. For each test at least 10000 events were acquired. Mixed lymphocyte reaction (MLR) CD4+ T cells were negatively selected from peripheral blood mononuclear cells (PBMCs) by using the T cell isolation kit II from Miltenyi Biotec. Mixed lymphocyte reaction (MLR) was performed in 96-well U
- bottom plates (Nunc). 1 × 105 CD4+ T cells were incubated for 5 days in RPMI with 10% FCS together with 1 × 104 to 1 × 103 allogeneic DCs. Experiments were conducted in quadruplicate. At day 5, the proliferative response was measured by the [3H]-thymidine ([3H]-Thy, 1 µCi/mL, Amersham) incorporation test
Peptides presenting the binding site of human CD4 for the HIV-1 envelope glycoprotein gp120
Beilstein J. Org. Chem. 2012, 8, 1858–1866, doi:10.3762/bjoc.8.214
- Based on the structure of the HIV-1 glycoprotein gp120 in complex with its cellular receptor CD4, we have designed and synthesized peptides that mimic the binding site of CD4 for gp120. The ability of these peptides to bind to gp120 can be strongly enhanced by increasing their conformational stability
- -amino acids. Keywords: biomimetic synthesis; CD4; HIV entry; peptide; protein binding site; Introduction Synthetic molecules that have the ability to mimic binding and/or functional sites of proteins are useful tools for exploring and modulating protein function, as they interfere with binding events
- protein binding site mimics. We have previously developed strategies for the design and generation of scaffolded and assembled peptides to generate protein binding site mimics [1]. The interaction of the HIV-1 envelope glycoprotein gp120 with its cellular receptor CD4 is the first step in the process of
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