Beilstein J. Org. Chem.2013,9, 2022–2027, doi:10.3762/bjoc.9.238
available from Thales). With a flow rate of 1 mL/min at 100 bar and 70 °C using a 10% Pd/C CatCart, a throughput of 8 mg/min was achieved. The crude reaction solution was pure by NMR and was used without further purification. As shown in Table 1, the hydrogenolysis represents a bottleneck in the synthesis
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Graphical Abstract
Scheme 1:
Batch synthesis of NBDM. a) NaNO2, Amberlite IR-120 H+ (100 mL), 0 °C, water, 4 h. b) NH2OH·HCl, Na...
Beilstein J. Org. Chem.2011,7, 1141–1149, doi:10.3762/bjoc.7.132
run-to-run reproducibility of the H-Cube® reactor for screening and reaction optimization is discussed.
Keywords: catalyst leaching; CatCart®; H-Cube®; packed bed flow hydrogenation; Introduction
The potential advantages of heterogeneous catalytic flow hydrogenation over traditional batch reactor
a convenient bench-top hydrogen flow reactor, the H-Cube®, designed for smaller-scale use in academic and drug discovery labs [6]. The reactor features a built-in hydrogen generator that functions by the electrolysis of water. Disposable pre-packed catalyst cartridges (CatCart®) are also available
]. Subsequently, ThalesNano commercialized the system developed by Ley and Ladlow. More recently, ThalesNano has introduced a CatCart Changer® (CCC) attachment with six CatCart® port positions and a column switcher to increase throughput and facilitate screening through multiple catalysts. These ThalesNano H-Cube
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Graphical Abstract
Scheme 1:
Reduction of 4-(4-azidopiperidin-1-yl)benzonitrile on the H-Cube®.