Beilstein J. Org. Chem.2023,19, 107–114, doi:10.3762/bjoc.19.11
. Antimalarial activity was significantly reduced when C-8 of the triazolopyrazine scaffold was substituted with CF3 and CF2H moieties, whereas incorporation of a CF2Me group at the same position completely abolished antiplasmodial effects.
Keywords: antimalarial; characterisation; DiversinateTM; fluorine
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Graphical Abstract
Scheme 1:
Synthesis of ether triazolopyrazine derivatives 4–9.