Cassane diterpenoids with α-glucosidase inhibitory activity from the fruits of Pterolobium macropterum

• Sarot Cheenpracha,
• Ratchanaporn Chokchaisiri,
• Lucksagoon Ganranoo,
• Sareeya Bureekaew,
• Thunwadee Limtharakul and
• Surat Laphookhieo

Beilstein J. Org. Chem. 2023, 19, 658–665, doi:10.3762/bjoc.19.47

• of isolated compounds was evaluated, and compounds 1 and 3 showed significant α-glucosidase inhibitory activity with IC50 values of 66 and 44 μM. Keywords: α-glucosidase inhibitory activity; cassane diterpenoid; Fabaceae; medicinal plant; Pterolobium macropterum; Introduction Diabetes mellitus is a

• and 6β-cinnamoyl-7β-hydroxyvouacapen-5α-ol, have been reported to exhibit significant α-glucosidase inhibitory activity [5]. The genus Pterolobium, comprising approximately 10 species distributed widely in Africa, China, and Thailand [6], is flowering shrubs belonging to Fabaceae. There are only four

Natural phenolic metabolites with anti-angiogenic properties – a review from the chemical point of view

• Qiu Sun,
• Jörg Heilmann and
• Burkhard König

Beilstein J. Org. Chem. 2015, 11, 249–264, doi:10.3762/bjoc.11.28

• xanthohumol intake [77]. To date, xanthohumol in vivo metabolites have not been investigated regarding their anti-angiogenic activity. Genistein Genistein (60) is an isoflavone extracted from soybeans (Glycine max (L.) MERR, Fabaceae). It is present as the 7-O-glycoside genistein in the plant; however, during