Beilstein J. Org. Chem.2021,17, 739–748, doi:10.3762/bjoc.17.64
ganglioside biosynthesis, and altered ganglioside status in cancer, and the effects on network structure are predicted. The simulator is available at the Glycologue website, https://glycologue.org/.
Keywords: gangliosides; Glycologue; glycosyltransferases; neuropathy; Svennerholm nomenclature; Introduction
O-linked glycosylation, with a web-based application, O-Glycologue, that allows knockouts of enzymes of O-linked glycosylation and the assignment of custom “wild type” sets of enzyme activities to study the effects of differential knockouts on the resultant networks [15]. In this article, we
describe an extension of this method to gangliosides, and to the enzyme reactions associated with their biosynthesis. The formalism and the associated web application, now renamed Glycologue, provide a way to explore the effects of mutations that result in a loss of functionality, or promotion of disease
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Graphical Abstract
Figure 1:
Chemical structure of ganglioside GM1a (a β-ᴅ-galactosyl-(1→3)-N-acetyl-β-ᴅ-galactosaminyl-(1→4)-[α-...
Beilstein J. Org. Chem.2020,16, 2645–2662, doi:10.3762/bjoc.16.215
integration into several formal-language compatible glycoinformatics tools including glycologue [41], glypy [42], glycome-db [43]; adoption LiCoRR or these wildcards in other glycan representations could shift glycan-database search from monosaccharide count to substructure class specification. While
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Graphical Abstract
Figure 1:
Common terminology and anatomy of a theoretical glycan, (KJ(IH)GF(D(E)(C)B)A. In this figure, we de...