Beilstein J. Org. Chem.2018,14, 1583–1594, doi:10.3762/bjoc.14.136
-conjugates containing doxorubicin, daunorubicin and methotrexate were investigated in this study. Their cytotoxicity was determined on primary human cardiac myocytes (HCM) and human umbilical vein endothelial cells (HUVEC) using the xCELLigence SP system, which measures impedance changes caused by adhering
: cardiotoxicity; drug targeting; GnRH-conjugates; HCM; HUVEC; impedimetry; Introduction
Gonadotropin-releasing hormone (GnRH) is a peptide hormone secreted by the hypothalamus, which stimulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Thus, it represents
detected. Conjugate 15 showed no significant cytotoxic effect on either short- or long-term (Figure 3g; Supporting Information File 2, Table S5a).
Measurements on human cardiomyocytes (HCM)
The effect of chemotherapeutic drugs (doxorubicin, daunorubicin, methotrexate)
Compared to their effect on
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Graphical Abstract
Figure 1:
Chemical structures of the GnRH-drug conjugates synthesized and investigated in the present work. A...