Microwave-assisted synthesis of N,N-bis(phosphinoylmethyl)amines and N,N,N-tris(phosphinoylmethyl)amines bearing different substituents on the phosphorus atoms

• Erika Bálint,
• Anna Tripolszky,
• László Hegedűs and
• György Keglevich

Beilstein J. Org. Chem. 2019, 15, 469–473, doi:10.3762/bjoc.15.40

• %). Synthesis of N,N,N-tris(phosphinoylmethyl)amines Finally, N,N-bis(phosphinoylmethyl)amines 13a and 13b were reacted further with paraformaldehyde and a secondary phosphine oxide (diphenyl-, di(p-tolyl)- or dibenzylphosphine oxide) to afford the N,N,N-tris(phosphinoylmethyl)amine derivatives bearing

• method for the synthesis of N,N-bis(phosphinoylmethyl)amines and N,N,N-tris(phosphinoylmethyl)amines bearing different substituents on the phosphorus atoms by the Kabachnik–Fields reaction. This method is a novel approach for the synthesis of the target products. In all, thirteen new derivatives were

• affording N,N,N-tris(phosphinoylmethyl)amine derivatives was also elaborated. This method is a novel approach for the synthesis of the target products. Keywords: (aminomethyl)phosphine oxides; Kabachnik–Fields reaction; ligand; microwave; N,N-bis(phosphinoylmethyl)amines; N,N,N-tris(phosphinoylmethyl