Microwave-assisted synthesis of N,N-bis(phosphinoylmethyl)amines and N,N,N-tris(phosphinoylmethyl)amines bearing different substituents on the phosphorus atoms

• Erika Bálint,
• Anna Tripolszky,
• László Hegedűs and
• György Keglevich

Beilstein J. Org. Chem. 2019, 15, 469–473, doi:10.3762/bjoc.15.40

• Erika Balint Anna Tripolszky Laszlo Hegedus Gyorgy Keglevich Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary 10.3762/bjoc.15.40 Abstract A family of N,N-bis(phosphinoylmethyl)amines bearing different substituents on the

• affording N,N,N-tris(phosphinoylmethyl)amine derivatives was also elaborated. This method is a novel approach for the synthesis of the target products. Keywords: (aminomethyl)phosphine oxides; Kabachnik–Fields reaction; ligand; microwave; N,N-bis(phosphinoylmethyl)amines; N,N,N-tris(phosphinoylmethyl

• the solvent to overcome the heterogeneity of the reaction mixture. After an irradiation of 1 h at 100 °C, the mixed N,N-bis(phosphinoylmethyl)amines 10a,b, 11a,b and 12a,b were obtained in yields of 92–97% and their structures were confirmed by 31P, 13C and 1H NMR, as well as HRMS measurements. Due to