Search for "N2-(tetrazol-5-yl)-6-aryl/heteroaryl-1,3,5-triazine-2,4-diamines" in Full Text gives 1 result(s) in Beilstein Journal of Organic Chemistry.
Beilstein J. Org. Chem.2020,16, 1706–1712, doi:10.3762/bjoc.16.142
performing green methodologies in the synthesis of biologically relevant heterocycles from simple starting materials [41][42][43][44], we developed an efficient synthesis of N2-(tetrazol-5-yl)-6-aryl/heteroaryl-1,3,5-triazine-2,4-diamines through the one-pot reaction of cyanamide 1, aromatic aldehydes 2, and
developed by reacting 5-amino-1,2,3,4-tetrazole with aromatic aldehydes and cyanamide in pyridine under controlled microwave heating with high yields. X-ray crystallography confirmed the structure of the obtained products.
Keywords: microwave irradiation; N2-(tetrazol-5-yl)-6-aryl/heteroaryl-1,3,5-triazine
-2,4-diamines; one-pot synthesis; X-ray crystallography; Introduction
The family of triazines is of considerable interest in fields related to organic and medicinal chemistry. 2,4-Diaminotriazines are privileged scaffolds exhibiting diverse biological activities such as antibacterial [1], anti-HSV-1
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Graphical Abstract
Scheme 1:
Previously reported methods for the synthesis of 1,3,5-triazine-2,4-diamine derivatives.