An expedient synthesis of 5-n-alkylresorcinols and novel 5-n-alkylresorcinol haptens

• Kirsti Parikka and
• Kristiina Wähälä

Beilstein J. Org. Chem. 2009, 5, No. 22, doi:10.3762/bjoc.5.22

• water solubility more generally, aryl modified phosphonium salts, carrying a –COOH group [38] or PEG attachments [39], have been developed but require extensive synthetic work. Previously, non-stabilized alkylphosphonium salts have appeared much less amenable than the benzyl analogues. A single paper

• alkyl bromide precursors are not available (Scheme 1). 5a was readily synthesised by Swern-type oxidation (see Supporting Information File 1). The Wittig reagents were poorly soluble in water. Nevertheless, functional groups enhancing their solubility, such as previously reported –COOH or PEG