Beilstein J. Org. Chem.2022,18, 722–731, doi:10.3762/bjoc.18.72
farnesylation of quinoline derivatives, such as 8-hydroxyquinoline-2-carboxylic acid (8-HQA) and quinaldic acid. The results of this study provide new insights into the abundance and diversity of Ptases in marine Flavobacteria and beyond.
Keywords: Flavobacteria; prenylation; Saccharomonospora; UbiA-like
biosynthetic repertoire of marine bacteria [14][15], the diversity of the encoded and yet often unexplored bacterial Ptases of Flavobacteria and Saccharomonospora strains sparked our interest. In this study we investigated three yet poorly described homologous Ptases within the UbiA superfamily and evaluated
their substrate scope by heterologous production and enzymatic bioassays. Results of our study showcase that marine bacteria harbor still a broad unexplored enzymatic repertoire.
Results and Discussion
In silico analysis of Ptases in marine Flavobacteria and the genus Saccharomonospora
In a first step
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Graphical Abstract
Figure 1:
Prenylated aromatic metabolites are involved in cellular processes like cell respiration (coenzyme Q...