Beilstein J. Org. Chem.2015,11, 2117–2124, doi:10.3762/bjoc.11.228
; lippidulcines; Saegusa–Larock; Introduction
It is a matter of fact that a large consumption of sucrose is strongly associated to a considerable number of undesirable health effects, among which cardiovascular diseases and dental caries are the most relevant. Moreover, the increasing number, especially in the
kinetic enol ether 10 in 91% yield ([α]D +19.7° (c 1.4, CHCl3)). The latter was submitted to the oxidative step with the IBX-N-oxide, but even in this case the results were unsatisfactory since only traces of enone 11 were detected. In contrast, the Pd based Saegusa–Larock methodology resulted successful
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Graphical Abstract
Figure 1:
Hernandulcin and other bisabolanic derivatives extracted from Lippia dulcis.