Beilstein J. Org. Chem.2021,17, 2417–2424, doi:10.3762/bjoc.17.158
bond of these oxadiazoles quantitatively resulted in E/Z-vinyl triflates. The reactions of the cationic intermediates have been studied by DFT calculations and the reaction mechanisms are discussed.
Keywords: acetylene-oxadiazoles; Friedel–Crafts reaction; hydroarylation; superelectrophilic activation
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Graphical Abstract
Scheme 1:
Synthesis of 5–arylethynyl-3-aryl-1,2,4-oxadiazoles 3a–e.