Synthesis of spiroannulated and 3-arylated 1,2,4-trioxanes from mesitylol and methyl 4-hydroxytiglate by photooxygenation and peroxyacetalization

• Axel G. Griesbeck,
• Lars-Oliver Höinck and
• Jörg M. Neudörfl

Beilstein J. Org. Chem. 2010, 6, No. 61, doi:10.3762/bjoc.6.61

• effects as the natural compound (Figure 1) [12]. An apparently useful structural feature is a large 3,3-spirofused hydrophobic group. The adamantane skeleton is a unique motif in other cyclic peroxides with antimalarial activities [13][14] which additionally exhibit other remarkable pharmaceutical

• exception of the adamantane derivative 5d which has a remarkably shorter O-O bond distance. 4-Arylated 1,2,4-trioxanes The 1,2,4-trioxanes 10 were formed in moderate to good yields, with the Hock-type cleavage product from the ß-hydroperdiol as the only side-product, from 4 and substituted benzaldehydes

Free radical homopolymerization of a vinylferrocene/cyclodextrin complex in water

• Helmut Ritter,
• Beate E. Mondrzik,
• Matthias Rehahn and
• Markus Gallei

Beilstein J. Org. Chem. 2010, 6, No. 60, doi:10.3762/bjoc.6.60

• cyclodextrin (Figure 3c). In addition, when potassium 1-adamantane carboxylate was added as a guest molecule, which competes with the complexed homopolymer solution, the polymer precipitated due to the hydrophobic character of the uncomplexed ferrocene. This uncomplexed polyvinylferrocene was investigated by

• complexation with cyclodextrin. The strong polymer-CD complex obtained remained unchanged up to about 90 °C. The removal of cyclodextrin by the addition of a competing guest, potassium 1-adamantane carboxylate, was demonstrated. Additionally, the polymer shows redox behavior even in the presence of the